Cloak, Dagger and DNA is if not the first then at least one of the first games ever to use make use of genetic algorithms. Each player (human or computer) controls an army which can be split up into smaller units and has to try to conquer the playing field and its resource-generating factories in a Risk-style manner of play.

Cloak, Dagger and DNA was developed by Oidian Systems and was planned to be part of a family of games around the theme of genetic algorithms, unfortunately interest was lacking and Oidian went out of business. Since then Don O'Brien (designer of the game) has released it as freeware.