Darkest Island is the story of a man named Daniel who wakes up in a bloody hospital bed on a remote island with no knowledge of how he got there. A girl's voice echoes in his mind, begging for him to come and rescue her, and promising to help him get off the island. Daniel finds that this hospital is actually a research facility, and the inhabitants are no longer human. These zombie-like creatures are not the only enemies that Daniel makes. Soon he has armed soldiers hunting him as well. The story of the facility unfolds as Daniel makes his way into the dark center of the island.