Dr. Mario is an arcade-style puzzle video game produced by Nintendo. It was originally released for the Nintendo Entertainment System and Game Boy in 1990. Its gameplay is often likened to that of Tetris. In this game, Dr. Mario throws vitamins that the player must align in order to destroy the viruses that populate the playing field (designed to resemble a medicine bottle). It is also a confirmed title to be available on Wii's Virtual Console.

A puzzle game similar to Tetris, Dr. Mario features Nintendo mascot Mario as a doctor. Play consists of dropping two-sided vitamin capsules into an eight-block-by-16-block playing field populated by viruses of three colors (red, yellow, and blue).