Sam & Max - a 6 foot dog in a 3 piece suit, and his hyperkinetic rabbity-type-thing pal - are self-dubbed "Freelance Police" who scour the globe for odd malformed versions of evil to defeat, though usually by accident.

In Situation: Comedy (the followup to Sam & Max: Culture Shock) Sam & Max must infiltrate a daytime talk show gone bad. Myra Stump, "the daytime hawk of TV talk," has kidnapped her audience and forced them to stay in the studio on the air for days, giving them free gifts and stern but motherly lectures against their will. To make it stop, Sam and Max must work their way through the local TV studio, starring in a series of nearly failed sitcoms, talent contests, quiz shows, and more along the way to prove themselves worthy of a spot on Myra's interview couch.